PhD position at the Institute of Biochemistry and Molecular Biology

The FeZa lab (www.fezalab.com) offers a position for a PhD student who is in for a challenge. ADP-ribosylation is traditionally known as protein posttranslational modification. Our recent work has shown that also RNA can be modified with ADP-ribose, with unknown function. We intend to figure out how ADP-ribose influences RNA function. This is an emerging field, with many open questions and possibilities to shape the research project.

The ideal candidate for this position has a background in biochemistry or cell biology. Desirable are experience with protein purification and biochemical characterization, or with Nanopore sequencing and bioinformatics. The expected start of this project is September 2023.

Relevant publications:

• Weixler, L., Feijs, K. L. H.*, and Zaja, R.* (2022) ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs. Nucleic Acids Res 2022, 50, 9426-9441.
• Weixler L, Scharinger K, Momoh J, Luscher B, Feijs K*, Zaja R*. ADP-ribosylation of RNA and DNA: from in vitro characterization to in vivo function. Nucleic Acids Res 2021, 49, 3634-3650.

To apply please send by email to Dr Roko Žaja (rzaja@ukaachen.de):

• A current CV
• A 1-page letter of interest
• The names of three potential referees

Application deadline: June 30, 2023