MSc By Research: Time and Space of TORC1 Signaling

The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master’s degree. It is designed specifically to enhance your skills for a PhD or research career. You can find further information about our academic requirements and programme structure here.

Join Us in Exploring the Exciting World of Cell Biology and Biochemistry!

Project Overview:

Cell growth is a dynamically regulated process responding to various external cues such as nutrient availability, growth factor signals, and stresses. At the heart of this regulatory network lies the Target of Rapamycin Complex 1 (TORC1 or mTORC1), an evolutionarily conserved kinase complex responsible for fine-tuning numerous cellular events. The key question we seek to answer is: How do upstream signals get sensed and transmitted to TORC1? This project will delve deep into the TORC1 pathway, exploring both its temporal (kinetics) and spatial (subcellular locations) aspects.

Project Objectives:

• Utilize our cutting-edge spatial TORC1 activity reporter system (as established in Hatakeyama et al., 2019, Mol Cell) to elucidate where, at the subcellular level, TORC1 senses different signals.
• Investigate the activation kinetics of TORC1, which exhibits a dual-phase response (fast and slow) to nutrient signals (Hatakeyama, 2021, Biomolecules).
• Uncover distinct molecular mechanisms governing TORC1 regulation in both time and space.

Model Systems:

As a master’s student, you will have the flexibility to choose between working with mammalian cultured cells or budding yeast, depending on your research interests and career perspective.

Main Techniques:

Microscopy; Western blotting; Immunoprecipitation; Mass spectrometry; Cell culture; Genome editing

Research Environment:

When you join our team, you’ll benefit from:

• State-of-the-art research facilities equipped with cutting-edge technology.
• Close supervision and mentorship from our dedicated and enthusiastic group leader.
• Weekly joint lab meetings involving six research labs, promoting collaboration and knowledge sharing.
• Monthly joint meetings at the institute-wide level, offering unparalleled networking opportunities and exposure to diverse biomedical research disciplines.

We are a forward-thinking research group at the forefront of TORC1 research. Your research will contribute to our collective understanding of fundamental cellular processes. We offer a supportive and collaborative research environment where your ideas and contributions are valued.

Don’t miss this chance to be part of groundbreaking research in cell biology and biochemistry. Apply now and take the first step toward an exciting and rewarding scientific journey!

For More Information:

If you have any questions or would like to learn more about this exciting opportunity, feel free to contact Dr Riko Hatakeyama at riko.hatakeyama@abdn.ac.uk.

Applicants to this project should hold a minimum of a 2:1 UK Honours degree (or international equivalent) in a relevant subject.

We encourage applications from all backgrounds and communities, and are committed to having a diverse, inclusive team.

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APPLICATION PROCEDURE:

Please note: This is a self-funded opportunity.

• Prospective students should contact the lead supervisor (via the email address listed above) to discuss the research project and complete a proposal form prior to / or shortly after applying.
• Formal applications can be completed online: https://www.abdn.ac.uk/pgap/login.php
• You should apply for Medical Sciences (MSc) to ensure your application is passed to the correct team.
• Please clearly note the name of the supervisor and the project title on the application form. If this is not included, your application may not be considered for the project.
• Candidates should have (or expect to achieve) a minimum of a 2:1 UK Honours degree (or international equivalent) at undergraduate level.
• Your application must include: a personal statement, an up-to-date copy of your academic CV, and clear copies of your educational certificates and transcripts.
• If you are still undertaking your undergraduate degree, it is helpful to the selection panel if you could provide documentation showing your grades to date (this can be a screenshot from an online portal).
• Please note: Project supervisors will not respond to requests for funding assistance.
• If you require any additional assistance in submitting your application or have any queries about the application process, please don’t hesitate to contact us at pgrs-admissions@abdn.ac.uk